One of the possible causes of vitiligo is attributed to oxidative stress, which leads to the destruction of melanocytes. Melanocytes are cells that provide color to the skin. In order to combat this mechanism, Dr. Karin Schallreuter and her colleagues created a topical cream called pseudocatalase. Pseudocatalase provides antioxidant properties to lower the levels of hydrogen peroxide (H2O2) on the skin and have shown favorable results(20).
In addition to other parts of the body, vitiligo commonly affects parts of the body with hair, such as the scalp, eyebrow, eyelash, and beard(2). These areas express lack of color in both the skin and hair. Therefore, the application of pseudocatalase may revive color in both the skin and hair in these areas. In a recent study published in 2013, the application of pseudocatalase has brought back color to the eyebrows and eyelashes in patients with vitiligo. This treatment has been successful in over 4000 patients worldwide(23). Repigmentation occurred in both nonsegmental vitiligo and segmental vitiligo, leading researchers to conclude that vitiligo is associated with high levels of H2O2/ONOO- mediated stress. Pseudocatalase reduces this epidermal oxidative stress, allowing repigmentation in areas of the eyelash and eyebrows affected by vitiligo. The article shows remarkable before and after photos of patients who have benefited from the treatment(23).
There is no scientific evidence at this time that pseudocatalase will prevent hair from going grey in areas unaffected by vitiligo(24). The current recommendation is that use of pseudocatalase be limited to patients suffering from vitiligo.